A comedy panel show favorite, Lock was a team captain on the series 8 Out of 10 Cats, hosted by Jimmy Carr.
He also made an appearance on QI, The Last Leg, Have I Got News for You, and The Big Fat Quiz of the Year.
Comedian Billy Bailey said, “It’s heartbreaking to lose my dearest friend Sean Lock, he was a true original, a wonderful comic.”
A statement from his agent Off The Kerb Productions said: “It is with great sadness that we have to announce the death of Sean Lock. He died at home from cancer, surrounded by his family.
“Sean was one of Britain’s finest comedians, his boundless creativity, lightning wit, and the absurdist brilliance of his work, marked him out as a unique voice in British comedy.
“Sean was also a cherished husband and father to three children. Sean will be sorely missed by all that knew him. We kindly request that the privacy of his family and children is respected at this difficult time.”
Sad news this morning 💔
Much-loved comedian Sean Lock has died, aged 58, his agent has confirmed.
The star – best known for his appearances on 8 Out Of 10 Cats Does Countdown – passed away after battling cancer. pic.twitter.com/LIgSdppd2y
— Metro (@MetroUK) August 18, 2021
Brutal news about Sean Lock today.
I loved him. I’m watching clips of him right now – laughing & crying. I’ll miss him so much.
— Jimmy Carr (@jimmycarr) August 18, 2021
Over 15 years producing '8 Out Of 10 Cats' Sean Lock made me laugh so much and so often. A unique and brilliant comic voice. Love to his family and his many friends #RIPSean
— Richard Osman (@richardosman) August 18, 2021
We're going to miss Sean Lock pic.twitter.com/PVXRPHF70m
— Radio X (@RadioX) August 18, 2021
Harry Hill on Sean Lock: ‘The comedian’s comedian who took us all by surprise’ https://t.co/NKCb2EjQOG
— The Guardian (@guardian) August 18, 2021
Lee Mack, a comedian, and close friend, also paid tribute to Lock saying, “I think the appeal of him as a viewer was that it felt like you were with your mate down the pub and he was making you laugh. I was one of the lucky few that was that mate down the pub and he was making me laugh. A lot. More than almost anyone I’ve ever known.” Lock, said Mack, could “talk about putting a budgie up his bum and yet levitate it into a hilarious art form”.